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KMID : 0605620150220040223
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Journal of Korean Society of Biological Psychiatry
2015 Volume.22 No. 4 p.223 ~ p.232
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The Correlation of Levels of Serum Lipid, Homocysteine, and Folate with Volumesof Hippocampus, Amygdala, Corpus Callosum, and Thickness of Entorhinal Cortexin Patients with Amnestic Mild Cognitive Impairment or Dementiaof Alzheimer’s Type
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이상준:Lee Sang-Jun
김태형:Kim Tae-Hyung/허량:Huh Lyang/최승은:Choi Seung-Eun/이봉주:Lee Bong-Ju/김경미:Kim Gyung-Mee/이정구:Lee Jung-Goo/김홍대:Kim Hong-Dae/문치웅:Mun Chi-Woong/김영훈:Kim Young-Hoon
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Abstract
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Objectives : In this study, the authors evaluated the correlation between levels of serum lipid, homocysteine, and folate with volumes of hippocampus, amygdala, corpus callosum, and in patients with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease (AD) type.
Methods : The study recruited patients who visited the dementia clinic of Haeundae Paik Hospital in Korea between March 2010 and June 2014. Among those, patients who had taken the neurocognitive test, brain magnetic resonance imaing, tests for serum lipid, homocysteine, folate, and apolipoprotein E (APOE) genotyping and diagnosed with aMCI or AD were included for analysis. Bilateral hippocampus, entorhinal cortex, amygdala and corpus callosum were selected for region of interest (ROI). The cross-sectional relationships between serum lipid, homocysteine, folate and ROI were assessed by partial correlation analysis and multiple linear regression analysis.
Results : In patients with aMCI, old age (> 80) and APOE ε4 carrier were associated with AD [odds ration (OR) : 12.80 ; 95% confidence interval (CI) : 2.25-72.98 and OR : 4.48 ; 95% CI : 1.58-12.67, respectively]. In patients with aMCI or AD, volumes and thickness of ROI were inversely correlated with levels of serum lipid and homocysteine. In multiple linear regression analyses, higher total cholesterol level was related to lower left, right hippocampus volume and left amygdala volume ; higher low-density lipoprotein cholesterol was related to lower right entorhinal cortex thickness ; higher homocysteine level was related to lower corpus callosum volume.
Conclusions : Higher serum lipid and homocysteine levels are associated with decreased volume of hippocampus, amygdala, corpus callosum and entorhinal cortex thickness in patients with aMCI or AD. These findings suggest that serum lipid and homocysteine levels are associated with AD as a modifiable risk factor.
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KEYWORD
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Alzheimer’s disease, Mild cognitive impairment, Cholesterol, Homocysteine
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